Journal: Optometry and Vision Science

Article Title: Association of retinal image–based, deep learning cardiac BioAge with telomere length and cardiovascular biomarkers

doi: 10.1097/OPX.0000000000002158

Figure Lengend Snippet: Diagrammatic representation of how the deep learning model and aggregation models are integrated to produce an individual's cardiac BioAge. *CLAiR is the deep learning model that produces the baseline cardiovascular risk score and comprises a series of deep learning models that first identifies which eye is being assessed, before analyzing the retina for a variety of biomarkers as described. *K-NN = K-nearest neighbors method. BioAge = biological age.

Article Snippet: Multiple confounding risk factors and reverse causation mean that any observed associations between leukocyte telomere length and cardiovascular disease should be interpreted with caution; however, studies using Mendelian randomization provide compelling evidence for a relationship between leukocyte telomere length shortening and an increased risk of both atherosclerotic cardiovascular events and an increased risk of hypertension., , Irrespective of the mechanism by which leukocyte telomeres shorten, our findings indicate that, whether assessed by traditional biomarkers or leukocyte telomere length, our novel cardiac BioAge DL model could be used as a novel surrogate biomarker for cardiac health.

Techniques:

Journal: Optometry and Vision Science

Article Title: Association of retinal image–based, deep learning cardiac BioAge with telomere length and cardiovascular biomarkers

doi: 10.1097/OPX.0000000000002158

Figure Lengend Snippet: Chronological and cardiac BioAge, categorized by mean Z -adjusted log T/S LTL ratio deciles for males and females

Article Snippet: Multiple confounding risk factors and reverse causation mean that any observed associations between leukocyte telomere length and cardiovascular disease should be interpreted with caution; however, studies using Mendelian randomization provide compelling evidence for a relationship between leukocyte telomere length shortening and an increased risk of both atherosclerotic cardiovascular events and an increased risk of hypertension., , Irrespective of the mechanism by which leukocyte telomeres shorten, our findings indicate that, whether assessed by traditional biomarkers or leukocyte telomere length, our novel cardiac BioAge DL model could be used as a novel surrogate biomarker for cardiac health.

Techniques:

Journal: Optometry and Vision Science

Article Title: Association of retinal image–based, deep learning cardiac BioAge with telomere length and cardiovascular biomarkers

doi: 10.1097/OPX.0000000000002158

Figure Lengend Snippet: Mean biomarkers for individuals in the top quartile of cardiac BioAge (Q1) compared with the bottom quartile (Q4) across all telomere length deciles

Article Snippet: Multiple confounding risk factors and reverse causation mean that any observed associations between leukocyte telomere length and cardiovascular disease should be interpreted with caution; however, studies using Mendelian randomization provide compelling evidence for a relationship between leukocyte telomere length shortening and an increased risk of both atherosclerotic cardiovascular events and an increased risk of hypertension., , Irrespective of the mechanism by which leukocyte telomeres shorten, our findings indicate that, whether assessed by traditional biomarkers or leukocyte telomere length, our novel cardiac BioAge DL model could be used as a novel surrogate biomarker for cardiac health.

Techniques:

Journal: Optometry and Vision Science

Article Title: Association of retinal image–based, deep learning cardiac BioAge with telomere length and cardiovascular biomarkers

doi: 10.1097/OPX.0000000000002158

Figure Lengend Snippet: Distribution of the mean biomarkers for male and female individuals in the top quartile of cardiac BioAge top quartile (TopQ) compared with the bottom quartile (BotQ), categorized by Z -adjusted log T/S leukocyte telomere length decile. BioAge = biological age.

Article Snippet: Multiple confounding risk factors and reverse causation mean that any observed associations between leukocyte telomere length and cardiovascular disease should be interpreted with caution; however, studies using Mendelian randomization provide compelling evidence for a relationship between leukocyte telomere length shortening and an increased risk of both atherosclerotic cardiovascular events and an increased risk of hypertension., , Irrespective of the mechanism by which leukocyte telomeres shorten, our findings indicate that, whether assessed by traditional biomarkers or leukocyte telomere length, our novel cardiac BioAge DL model could be used as a novel surrogate biomarker for cardiac health.

Techniques:

Journal: Nature Communications

Article Title: Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination

doi: 10.1038/ncomms10369

Figure Lengend Snippet: ( a ) BioAge classification of the 135 elderly patients based on gene expression prior to vaccination is significantly associated with the response to HBV vaccination. Each bar of the bar plot represents one of the elderly participants in the EM131 cohort. The height of the bar indicates the BioAge score of that donor. Bars were ordered by increasing level of the BioAge, separately for the HBV poor-responders (in red) and HBV responders (in black). Fisher's exact test P values are given on the plot. ( b ) Forward selection among the modules composing the BioAge signature resulted in the selection of modules M1 and M16 as optimal signatures, predicting HBV vaccine response in the EM131 elderly cohort (age≥65). ( c ) Pathway enrichment analysis on the genes included in modules M1 and M16 using the IPA canonical pathway database. Fisher exact test was performed to assess statistical enrichment and gene sets with FDR-corrected P value≤0.05 are presented.

Article Snippet: In the BioAge M16, IRF7 (the master switch of type I interferon) and its downstream targets IL-15 and OAS1 , as well as NFkB and C1 (hallmarks of inflammation) were associated with lower Ab titres.

Techniques: Gene Expression, Selection

Journal: Frontiers in Nutrition

Article Title: Effect of dietary inflammatory potential on the aging acceleration for cardiometabolic disease: A population-based study

doi: 10.3389/fnut.2022.1048448

Figure Lengend Snippet: Characteristics of participants across the tertiles of the dietary inflammatory index.

Article Snippet: KDM BioAge, years , 49.6 (19.7) , 49.1 (18.5) , 49.7 (19.8) , 50.2 (20.9) , 0.009 .

Techniques: